Anderlecht
Anderlecht have fresh selection concerns after Marten Winkler and Thelo Aasgaard both missed Wednesday's training. Winkler was already absent for the 4-1 league victory over Westerlo, while Aasgaard played the full match and scored. Vítor Bruno has yet to confirm whether either will be ready to face Salzburg.
The weekend win was an important response to the heavy defeat at Gent, but it also brought a midfield dilemma. Ilias Koutsoupias started against Westerlo but is not on Anderlecht's UEFA squad list. Enric Llansana, who started at Gent and featured as a substitute against Jagiellonia, is therefore a realistic option alongside Mario Stroeykens and Lukáš Ambros. Mihajlo Cvetković is the likely focal point up front, with Jayden Onia Seke and Tristan Degreef competing for wide roles if Winkler cannot play. At right-back, Kaïs Barry and Ali Maamar offer two different selections after starting the recent European and league fixtures respectively.
Red Bull Salzburg
Danny Röhl must reshape Salzburg's defence after the club ruled out Kévin Boma with a calf injury. John Mellberg, Dominik Schmid and Nikolas Veratschnig are also unavailable. Leandro Morgalla returned from the bench against Austria Lustenau, making him an option at right-back, while Tim Drexler and Valentin Zabransky could form the central pairing.
The attacking picture is considerably brighter following Sunday's 5-1 win. Yorbe Vertessen scored the opener, with Frans Krätzig, Drexler and Abubakr Barry also finding the net. Haris Tabaković is expected to lead the line again, supported by the pace of Edmund Baidoo and Gaoussou Diakité. Röhl has stressed the importance of maintaining concentration throughout the match after Salzburg's previous European draw at Celje.
Salzburg are still without Sota Kitano and Justin Omoregie, and the club has not settled the availability of Jesper Lindstrøm or Damir Redzic. Those doubts strengthen the case for Abubakr Barry and Bartosz Mazurek in central midfield, with Soumaïla Diabaté another available candidate.